Musculoskeletal Pathophysiology

HST.021 Musculoskeletal Pathophysiology

January (IAP) 2006

The Gout. James Gillray, 1799. From the Philadelphia Museum of Art.

Staff

Instructors:
Dr. Dwight R. Robinson

Guest Lecturers:
Dr. Paul Joseph Anderson
Dr. Robert Horatio Brown, Jr.
Dr. Marie Demay
Dr. Stephen Martin Krane
Dr. Young-Jo Kim
Dr. Henry Jay Mankin
Dr. Bjorn Reino Olsen
Dr. John Thomas Potts
Dr. Alan Lewis Schiller
Dr. Brian Dale Snyder

Course Meeting Times

Lectures:
Three sessions / week for 4 weeks
2 hours / session

Level

Graduate

Course Highlights

This course features a selection of downloadable lecture notes. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month.

Course Description

This course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.

• Course Home
• Syllabus
• Calendar
• Lecture Notes
• Assignments
• Exams
• Related Resources
• Download Course Materials

Syllabus

Overview

This lecture based course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.

Assignments

There is one problem set and a final exam for this course.

Grading

Activities	Percentages
Problem Set	10%
Final Exam	90%

Lecture Notes

Below is a selection of lecture notes courtesy of Prof. Dwight Robinson.

SES #	TOPICS	LECTURE NOTES
1	Bone Growth and Development (1 hr.) - Dr. Schiller Bone Growth; Fracture Healing (1 hr.) - Dr. Schiller
2	Infections of Bone/Metabolic Bone Disease (1 hr.) - Dr. Schiller Histology of Bone; Microscopic Lab (1 hr.) - Dr. Schiller
3	Disorders of Growth Plate (1 hr.) - Dr. Olsen Heritable Disorders of Connective Tissues (1 hr.) - Dr. Krane
4	Basic Skeletal Biomechanics (1 hr.) - Dr. Snyder Biomechanics of Fracture Healing (1 hr.) - Dr. Snyder
5	Cartilage Biology and Biomechanics (1 hr.) - Dr. Kim Biomechanics in Pathogenesis of Osteoarthritis (1 hr.) - Dr. Kim
6	Rheumatic Diseases (I) (1 hr.) - Dr. Robinson Rheumatic Diseases (II), SLE, Scleroderma (1 hr.) - Dr. Robinson	(PDF - 1.2 MB)
7	Pathogenesis of Rheumatoid Arthritis (1 hr.) - Dr. Anderson Rheumatic Diseases (III), Vasculitis, Gout (1 hr.) - Dr. Robinson	(PDF)
8	Biomechanics Review Session (1 hr.)
9	Muscular Dystrophies/ Inflammatory Myopathies (1 hr.) - Dr. Brown Mitochondrial Myopathies (1 hr.) - Dr. Johns Mineral Ion Homeostasis (2 hrs.) - Dr. Potts
10	Osteoporosis; Osteomalacia (1 hr.) - Dr. DeMay Cartilage; Structure Osteoarthritis (1 hr.) - Dr. Mankin Demonstration: Joint Dissection (30 min.) - Dr. Mankin
	Final Examination (2.5 hrs.)

Exams

Final Exam (PDF)

Solution to Final Exam (PDF)

8(^_^)8